Obesity and telomere length, a study reveals all!

Once bitten twice shy: Telomere length and obesity

Recent research on the subcutaneous tissue of obese formerly obese and never obese patients revealed some fascinating findings.

In summary:  Obese patients had shorter telomeres in their subcutaneous fat.
Formerly fat people had shorter telomeres as well, suggesting that this may be an irreversible consequence of obesity.

The never obese had longer telomere length than either of the experimental groups.

While the study was small it is fascinating because it implies that once you lose telomere length you cannot get it back, or at least no one in this small group of study participants did!

This underscores the need for a telomerase activator like TA-65 as the only current way to lengthen your telomeres.  At this point TA 065 data is strongest in lengthening the most damage in critically short telomeres rather than mean telomere length. (MTL)

MTL is a very broad imprecise measure and may take well over a year to come up.  It is also possible that TA65 ONLY works on the shortest telomeres which are the ones most in need of repair and lengthening.  This is fine actually since normal length telomeres cause no problems and if they were to shorten they would presumably be repaired as well.

AS we clarify more to the science especially the science of measuring telomeres, we will undoubtedly get more positive data about the effects of telomerase activation.

But in the meantime watch your weight because once bitten twice shy!
The Telonauts



It’s On!

I thought you might like to see the schedule for Fitcamp which is less than one month away now (April 14-18 www.fitcamp.com)

WE do have an addition as well which is not shown here and that is we have an Active Isolated Stretching Expert coming down as well. AIS is not only the hottest thing in stretching it is probably one of the few ways you can rapidly efficiently develop flexibility for sports. Those of you who do a lot of Yoga will be amazed at how much your posture improves using this technique and how fast they improve as well.

I am primarily interested in it to fix my lousy biomechanics for running LOL so there are many applications.

AS you can see I have a few cameos as well and I am proud to be along side such an erudite group!

There is still time and a few rooms left if you realize as we do that this is a totally new animal and something that has not been done before.

Dr Dave

FITCAMP Cancun
Tentative Schedule

Tues. April 13
Early Registration All Day
5PM Early Birds Power Walk Workout on Beach
6PM Team Leaders Meeting

Wed. April 14
Registration All Day
7:30 AM Meditation
8 AM Yoga (all levels)
9AM Breakfast
10AM Power Walk (option)
Hell Hike (option)
11:30 Butts N Guts or Pool Workout
12:00 – 1:00 Lunch
**1:00 – 5PM FULCRUM
6:00 “The Details on D” (Vitamin D Seminar with Dr. Joe Mercola)
7:00-8:00 Dinner
8:00 Telomere Talk with Bill Andrews, PhD
**9:00Team Building Before Bedtime with Fulcrum Learning Systems

Thursday April 15
7:15 Meditation
HellHike (option)
8:00 Yoga (Level 1-2 on Pier) (Level 2-3 White Lotus Yoga with Fran)
Yoga for Stiffies with Greta B
9:00 Breakfast
**10:00 Teamwork and Motivation with Fulcrum Learning Systems)
12:00 Sprint 8 Theory & Workout (option)
1:15 Lunch
3:00 Anti-Aging Strategies with Dr. Dave
4:00 Sunset Yoga
Sprint 8 (option)
Beach /Pool (option)
5:00-5:30 Butts N Guts (option)
Beach/Pool (option)
6:00 Dinner
7:30 Ask The Experts Seminar (Dr. Dave, Greta B, Dr. Mercola, Bill A, Phil C)

Friday, April16
7:15 Meditation
Hell Hike (option)
8:00 Yoga (all levels options)
9:00 Breakfast
10:00 UltraRunning with Bill A Seminar, plus Phil C Training Tips
Fun Run w/Dr. Dave or Power Walk w/GB (option)
11:00 Sprint 8
11:30 Pool Workout or Butts N Guts
12:30-1:30 Lunch
1:30 Hormones 101 (for men and women) with Dr. Dave
2:00 TBA
3PM Sprint 8 (option)
Beach/Pool (option)
4:00 Sprint 8 (option)
Beach/Pool (option)
5:30 Dream Team Seminar
7:00 Dinner
8:00 Seminar TBA

Sat April 17
7:15 Meditation
Hell Hike (option)
8:00 Yoga (all levels)
9:00 Breakfast
10:00 Fat-Burning Secrets Seminar
11:00 Sprint 8
11:30 Pool Workout
12:00 Lunch
1:00 Diagnostics: What Tests You Should Get and Why/Dr. Dave
2:00-5:00 Tour options/Hotel bikes or kayak rentals
6:00 Sprint 8 (option)
Workout option TBA
7:00 Dinner
8:00 Talent Show/Awards/Dream Team

Sun April 18
7:15 Meditation
Hell Hike (option)
8:00 Yoga (all levels)
9:00 Breakfast
10:00 Taking It Home With You (seminar)
11:00 Sprint 8 ; options/TBA)
Departures throughout the day

Good Paper, Bad Press Release

We tapped our fellow telonaut and uber-researcher in the anti-aging field, Dr. Bill Andrews for his comments on the paper mentioned in the last blog entry.

Here is what he had to say

“The paper shows for the first time that free radical production plays a role in inducing senescence apart from its role in causing telomere shortening. That is, senescence; whether or not it is induced by short telomeres, stress, or oncogenes; is initiated by the DNA Damage Response (already known) and this induces free radical production (not known before) through DNA Damage Response induced mitochondrial dysfunction. The free radical production in turn helps maintain the DNA Damage Response (i.e., a feed back loop). And, all this maintains senescence related proliferation arrest.”

We would add that we know that short telomeres are also a stimulus for the DNA damage response and are essentially treated as a double strand break.

No one in the Telonauts ever said or meant to imply that short telomeres were the only thing that could kill a cell or the only reason why cellular senescence happens.  But they are clearly a big piece of the puzzle and often the end arbiter of the response.

The big thing the mentioned paper showed was not the lack of importance of telomeres, but the role of the cellular powerhouses – the mitochondria – in fueling the fire that ultimately burns up the cell with free radicals.  In this case for the reason of keeping sick and dying cells or mutated cells from living longer when they should not. We knew about the DNA damage response, we knew about its role in controlling the proliferation of sick or deadly cells like cancer, but no one had proven the role of the mitochondria as the suicide squad.

Just remember this: healthy cells have long telomeres!

Oh, and one other thing directed at Passos et al who produced this important paper… we think this kind of research deserves a professional writer for the press release.  If you need help next time we are available!

The Telonauts

All Aboard!!!

AS you might guess there are a lot of people jumping on the telomere/telomerase bandwagon.

Also somewhat amusing is the opposite group — mainly scientists whose vested interest in research and the money that comes from it — who depend on  telomeres/telomerase not being all that important.  They’re  out here too and the press releases are starting to flow, complete with poor grammar, lousy English, and all directed at getting people to think about other mechanisms of aging.

WE are sure there are other mechanisms.  We are sure that the telomere is not the only place where aging and disease act.  But we are also sure that it DOES act in aging disease and is one of the critical pathways that need to be addressed to prevent and reverse human aging.

We the Telonauts test things because we are writing a book called The Immortality Edge which is out in December of this year and gives people simple specific guidelines on how to keep their telomeres longer and how to add length to this critical “biologic time clock” segment.

So far, there have been a whole host of imposters that claim to turn on telomerase and lengthen telomeres or “imply” it — but we can tell you flat out none of them work.

We can tell you that because we have tested them!

If and when we find one other than the one that does work (TA-65) we’ll let you know and let you know fast.

Next let’s discuss one press release that refers to telomere biology and aging as “pretending”

Researchers at Newcastle University claim THEY have the answer to aging.  When a cell ages it sends signals to the brain and those distress signals also create mitochondrial excesse release of free radicals that eventually stop the cell from dividing by — you guessed it — affecting telomere length.

So even the naysayers can’t get away from using the words telomere length in their writings.

Now in truth I doubt even this gang of researchers is proud of the press release that came out on their behalf. It is so poorly written and does not convey the concepts clearly other than they are upset that telomeres are getting so much attention.

LOL!

Rest assured, aging is a complex process and more research is needed.  But telomeres, telomerase, and telomerase length and health are at the core of a very complex problem and deserve all the attention they are getting!

- The Telonauts

Wow! What a culture we live in!

It would seem that what people want and what they are willing to do to get it are at direct odds with each other. Most people say they want to live longer and healthier, but they are not willing to do the things they need to do to get there.

Eat right, exercise right, sleep right, and relieve stress so it does not erode your brain, your body, your blood vessels, your relationships, and yes your telomeres which you should know if you are listening to Greta And Michael every Monday night on the Telonauts radio show on 7thwaveradionetwork.

Why aren’t people willing to do the right things?

I have a theory.

First, I think most people are reactive and let the immediacy of life move them off their long term plans (if they even make them).

Next, I think that most people really don’t actually believe that it’s possible to live longer and better by more than say a few years compared to our parents.

Nothing could be farther from the truth.  I can tell you that when the new census data comes out you’ll see a huge jump in the aged population, bigger than ever anticipated. But you’ll also still see the average age of people only going up by a few years compared to before.

So when you see pockets of people living longer, what are you seeing?

At this point primarily genetics because the interventions that will add years and health to our life have just begun to be adopted by enough people to affect the overall average or median age data.

Take for instance fish oil.

A recent study compared people who took fish oil with people who did not. In this particular group they were looking at folks who already had heart disease, not normal healthy people. The end result was the biological time clocks we call “telomeres” were longer the more fish oil people took. It translated into almost a decade of lifespan difference.

Now we need to go back and see if they are healthier.

Oh wait, we’ve already done that! As a matter of fact we’ve been doing that for 40 years now and everything from arthritis to Alzheimer’s seems to respond to fish oil.

Now remember fish oil is not a telomerase activator. We’ve tested it. It’s also not a telomerase inhibitor, unless you get cancer which is pretty much exactly the kind of behavior you want from a supplement.

ON when you need it, OFF when you need it.

So how does fish oil preserve telomere length without actually adding to the length?

Most likely it protects the telomere from degradation the way many other anti-oxidants do and it causes the expression of favorable protective elements and reverse inflammation that would degrade the telomere segment.

Are there other ways to save the telomere and lengthen it?

Sure there are, but we are still in the research phase.  So for the moment, we can only tell you that all will be revealed as you stay tuned to this blog, our radio show with Greta And Michael, and of course our book, “The Immortality Edge,” which we are feverishly writing and researching as we speak.

This while thing is going to blow up in a very good way for all of us especially YOU!

So stay tuned and recruit your friends and the ones you love to become Telonauts.

You have no idea how worth it’s going to be!

Pushing the Hayflick Limit!

– Greta, Michael and the rest of the Telonauts.

Dr. Dave on Longevity

Get to Cancun!

Dear Friends,

The Cancun Camp this year will have a terrific anti-aging focus that will be the underpinnings for ALL of us as time marches on.  We all want to stay young and healthy for as long as possible, right?  For this reason, we picked the theme: NUKE AGING!

For those of you who are personal trainers, it will give you the inside edge when it comes to having something NEW to offer clients. It doesn’t hurt that Ceiba del Mar, the resort we have booked, is gorgeous and the healthy food is five-star.

You can fly into camp a day or so early if you want to extend your visit. We have a very special rate at the resort and can help you make that happen if you’d like. Otherwise, fly down Wednesday, April 14, as early as you can so that we can get the ball rolling by noon and depart on Sunday, April 18, anytime after noon so that we can have a full-tilt BLAST OFF from camp that day.

If you register NOW with a $250 dollar deposit you get some special goodies like a pre-camp CD with an interval training workout as well as a pre-camp GOODY BAG with fantastic supplements.

Note that the camp fee ($1595 STANDARD shared room, and $2295 DELUXE single room) includes everything at camp except your airfare and airport transfers to and from the resort. We can help arrange your transportation from the airport and back via a van that costs $90 and holds 6 people at a time. We also have a travel agent we have worked with for nearly 15 years and she is great at helping campers get good air deals.

Following is a sample list of the classes we will feature at FITCAMP Cancun: NUKE AGING!

Hell Hikes
These daily “grinds” are a special treat at FITCAMP. Once you’ve conquered our special Cancun version of Hell Hill you’ll never be the same. You go at your own pace and have the support of the entire group in helping you make your way through this revolutionary new way to work out that is being debuted at this camp. Fitness champs can lead the pack and break existing camp speed records if they want a real challenge. Either way, everyone gets to finish.

We’ll even teach you how to create a Hell Hike in your hometown so that what you learn at camp goes back home with you.

Obstacle Course
For those wanting a real bootcamp experience, this is it. Speed, balance, agility, focus, strength, and flexibility all come into play on this timed course. There are awards given out for Best Individual, Best Team and Best Effort.

Abs 101 and Advanced Abs
Ever dream of having a 6-pack? We’ll show you how. Whatever your fitness level we’ll work your stomach and core in ways you’ve never seen before.

Yoga
Are you a devoted yogini? Then these classes will heighten your practice.
Never tried it, but wanted to? Learn the basics from our pros.
The style of yoga taught at FITCAMP is a groovy vinyasa style that allows for variations for all levels.

Sprint 8
You haven’t heard of it ..yet. But you will! This camp exclusive is the answer to your prayers. We’ll teach you the secrets of high-intensity interval training interspersed with low intensity intervals for recovery. You can use this with your workouts at home whether they’re biking, running, walking, swimming, or weight lifting.

You’ll build muscle, lose fat, increase feel-good hormones and get anti-aging benefits to boot. Better yet, the guy who invented it will be the guy teaching you at camp. Doesn’t get better than that.

TEAM BUILDING and MOTIVATION
Challenge yourself and break through to new ways of being. You’ll conquer your fears and create powerful new goals. No one pushes you beyond what YOU want to do but watch out! At the FITCAMP people have been known to become outrageous, courageous warriors like never before. You just might have some untapped potential that even you are unaware of. The folks back home may not recognize you after this one.

More…..

Supplements That Work: Dr. Dave Woynarowksi is the internet supplement guru from drdavesbest.com He will cut thru the crap and teach you what you really need to keep going at age 40, 50, 60 and beyond. He is a nationally recognized authority on anti-aging and the guy you see on TV talking up the latest in the field.

Superstars of Science: FITCAMP guests will include leading researchers and authors in the field of anti-aging research. They will share the top tips that are being investigated in labs around the world. You may come away from camp knowing more about telomere biology and stem cells than your doctor! We are firming up our Special Guest list and will have announcements soon about this hotshot line-up.

Please call me anytime with further questions (800/727-2888). And direct your friends to www.fitcamp.com so that they can sign up as well. FITCAMP is addictive!

Love ya!

Greta B. 

To Age or Not To Age…

That is the question.

A lot of people ask me what is the best program to make sure I age as gracefully as possible and grow younger if possible.

So I have distilled it down to the basics for you.

You can use the acronym “AGE-ING” to see how you are doing.

“A” is for attitude. As much as traditional medicine tries to fit us into a mechanical box and treat us as if we have no soul, human beings are emotional and spiritual beings. This aspect has been overlooked for decades if not centuries in the Cartesian approach that most doctors practice today.

Can stress cause disease? We know it can. Is stress quantifiable?
Not really. Is there a mechanical equivalent that meets the human description of stress? Not really.

So the drug companies can come up with poor second guesses that have tons of side effects.

The whole Prozac class is an example.

We stop the reuptake of the chemical serotonin so people with low serotonin feel better. Eventually, however, slowing the reuptake doesn’t work because not enough is being made.

So the doctor hands you a bigger pill and a bigger pill with more side effects.

And they call anti-aging quackery!

Sleep Wizard provides the raw materials your body needs to make more serotonin.

But the FDA and the FTC say I can’t recommend it for anything so go ahead and enjoy your Ambien.

Hope you like the taste of buttered cigarettes!

“G” is for genetics. You can modify your genetics by a lot of things.

One of them is diet. In this vein you can also use supplements like fish oil, which has been shown in numerous lab studies.

If you are predisposed to being fat add some Regenerizer to the fish oil and watch your body change.

If your family history is rife with inflammatory diseases of aging like heart disease, stroke, Alzheimer’s, arthritis, etc., then go for the extra power of Super Omega 3.

If you are getting older and your body is starting to lose fat and muscle – use the Hercules Factor – our best selling Growth Hormone secretagogue with the ability to enhance the action of testosterone built in for maximum punch.

Or just get old, weak and fat like you’re supposed to.

After all Anti-aging is quackery, right?

“E” is for exercise. Sorry but you can’t get away without this. Regular scheduled exercise of the weight bearing type is the best. Walking is fine but if you can do more, by all means do so. I have written tons of exercise-rich emails for everything from your abs to the best cardio.

All of them are on my site archives.

The studies show that exercise helps maintain overall health, ideal body weight, and is associated with better mental function and balance.

Just don’t make the cardinal mistake many serious athletes do.
Exercise can and does burn out the body if the free radicals it creates are not buffered.

I use Cardio Booster and Super Wrinkle Guard because they are the best antioxidants on the market.

If you are serious about your exercise or if you are just getting started, give your body a break before it breaks!

“I” is for Intellectual stimuli. Keeping your brain stimulated with
hobbies, complex thought-requiring tasks like puzzles and problem solving provides the exercise your mind needs to stay its youngest.

Instant Brain Power was designed to boost the capacity of your brain for memory, creativity, focus and concentration.

Next, to the fish oil; it remains my favorite supplement. There is no way I could write all the things to you I do so frequently without a little help from Instant Brain Power!

“N” is for nutrition. I will not belabor this point but I have written even more about diet than exercise. From the metabolic seminars to the recent “Maximum Fat Burning” series just about any question you could ask is answered right here in the daily emails.

So keep reading!

“G” is for getting rid of drug dependency. By educating yourself about what Mother Nature has to offer you are fighting Big Pharma and taking control of your health and your future.

How dare you!

This is outlandish and anyone telling you that you are smart enough to do so is a quack. Remember the only thing you can really do is quit smoking and drinking, wash your hands and spend your retirement putting money in Big Pharma’s pocket, only to wind up bed ridden and in a nursing home.

And for heaven’s sake make sure you ignore that anti-aging quackery because it might speed up the decline of Big Pharma supported medicine.

As if they needed any help!

Give ‘em enough rope and they’ll hang themselves. This week’s disaster was death and liver failure from the antibiotic Ketek.

There’s more to come, I promise you.

In the meantime stay young and stay free.

All the supplements mentioned in this email can be found below but remember they are the product of an anti-aging quack and couldn’t possibly be helping the thousands of people who write in every year to thanks us for what we do.

- Doctor Dave